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Guy A. Rouleau

Biography, Career summary, research topics and interests

Biography, Career summary, research topics and interests

Guy A. Rouleau, MD, PhD, FRCP(C) is the Director of the CHU Sainte-Justine Research Center and a Full Professor at the Department of Medicine of the Université de Montréal. He also directs a pan-university institute, the "Centre d’étude des maladies du cerveau", at the Research Center of the CHUM – Hôpital Notre-Dame. For the last 20 years, his work has focused on understanding the genetic basis of brain diseases. He has, among other things, mapped more than 20 loci and made a major contribution toward the identification of more than 10 genes responsible for diseases as well as a better understanding of their pathogenesis.

Dr. Rouleau’s work deals with various neurological and psychiatric illnesses with a genetic component, including amyotrophic lateral sclerosis, cerebrovascular accidents, familial aneurysms, cavernous hemangiomas, epilepsy, spinocerebellar ataxia, spastic paraplegia, autism, Tourette’s syndrome, restless legs syndrome, schizophrenia and bipolar disorders. His laboratory’s research work also revolves around the understanding of the pathogenesis of amyotrophic lateral sclerosis, oculopharyngeal muscular dystrophy and CAG triplet repeat disorders, using cell and animal models.

Dr. Rouleau has trained a large number of scientists and physicians whom now hold various academic positions at universities.

Publications <+>
Significant publications

Hand CK, Khoris J, Salachas F, Gros-Louis F, Simoes Lopes AA, Mayeux-Portas V, Brown RH, Meininger V, Camu W, Rouleau GA, A novel locus for familial amyotrophic lateral sclerosis, on chromosome 18q, Am J Hum Genet 70, 251-256, 2002.

Howard HC, Mount DB, Rochefort D, Byun N, Dupre N, Lu J, Fan X, Song L, Riviere JB, Prevost C, Horst J, Simonati A, Lemcke B, Welch R, England R, Zhan FQ, Mercado A, Siesser WB, George AL, McDonald MP, Bouchard JP, Mathieu J, Delpire E, Rouleau GA, The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum, Nature Genetics 32, 384-392, 2002.

Duan QL, Nikpoor B, Dubé MP, Molinaro G, Meyer IA, Dion P, Rochefort D, Saint-Onge J, Flury L, Brown NJ, Gainer JV, Rouleau JL, Agostoni A, Cugno M, Simon P, Clavel P, Potier J, Wehbe B, Benarbia S, Marc-Aurèle J, Chanard J, Foroud T, Adam A, Rouleau GA, A variant in XPNPEP2 is associated with angiodema induced by angiotensin I-converting enzime inhibitors, Am J Hum Genet 77, 617-626, 2005.

Gros-Louis F, Dupre N, Dion P, Fox MA, Laurent S, Verreault S, Sanes JR, Bouchard JP, Rouleau GA, Mutations in SYNE1 lead to a newly discovered form of autosomal recessive cerebellar ataxia, Nature Genetics 39, 80-85, 2007.

Valdmanis PN, Meijer IA, Reynolds A, Lei A, Macleod P, Schlesinger D, Zatz M, Reid E, Dion PA, Drapeau P, Rouleau GA, Mutations in the KIAA0196 gene at the SPG8 locus cause hereditary spastic paraplegia, Am J Hum Genet 80,

More Publications <+>
More publications

Awards and distinctions

1993, Scientifique de l’année, Société Radio-Canada
1994, Un des Grands de l’année, Magazine l’Actualité
1999, Prix Léo-Parizeau, Association canadienne-française pour l’avancement des sciences (ACFAS)
2000, Michael Smith Award, Canadian Institutes of Health Research
2000, Professionalism Award, Faculty of Medicine, University of Ottawa
2002, Personnalité de la semaine, La Presse
2007, Henry-Friesen Award, The Royal College of Physicians and Surgeons of Canada

Canada, the USA, Japan, Brazil and Europe. He has published more than 380 peer-reviewed articles, many of which in Nature, Nature Genetics and the American Journal of Human Genetics. He has won various awards for his contributions to science and society, such as Scientifique de l’année (1993, Societé Radio-Canada), Un des Grands de l’année (1994, Magazine l’Actualité), Prix Léo-Parizeau (1999, Association canadienne-française pour l’avancement des sciences-ACFAS), the Michael Smith Award (2000, CIHR) and the Henry-Friesen Award (2007, The Royal College of Physicians and Surgeons of Canada.  He has also sat on many grant evaluation committees (ex. CIHR, NIH, ALSA, NNFF, FRSQ) and executive committees (ex. Genethon, Fondation Jean Dausset – CEPH, National Ataxia Foundation, Xenon Genetics Inc, Emerillon Therapeutics Inc, Biocapital Inc.).

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