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Marie-Pierre Dubé – Biography

Career summary, research topics and interests

Marie-Pierre Dubé is assistant professor in the Department of Medicine at Université de Montréal and leads the statistical genetics research group at the Montreal Heart Institute. She works on the genetic epidemiology of heart diseases. She also directs the statistical analysis for a large pharmacogenomic study at the Montreal Heart Institute on drug efficacy and toxicity of lipid lowering drugs used in the treatment of dyslipidemias and atherosclerosis. Marie-Pierre completed her Ph.D. on the topic of statistical genetics at McGill University in 1999, followed by postdoctoral work at University of Toronto in genetic epidemiology of cancer. Before coming to Université de Montréal, she directed the statistical genetics group at Xenon Pharmaceuticals, Inc., where she participated in the discovery of important disease genes in the areas of dyslipidemia, iron metabolism, and neurological development and function.

Significant publications (+)
Effects of AGTR1 A1166C Gene Polymorphism in Patients with Heart Failure Treated with Candesartande Denus S, Zakrzewski-Jakubiak M, Dubé MP, Bélanger F, Lepage S, Leblanc MH, Gossard D, Ducharme A, Racine N, Whittom L, Lavoie J, Touyz RM, Turgeon J, White M.Ann Pharmacother. 2008 Jul 1; [Epub ahead of print]
Genetic predictors of depressive symptoms in cardiac patients. McCaffery JM, Duan QL, Frasure-Smith N, Barhdadi A, Lespérance F, Théroux P, Rouleau GA, Dube MP. Neuropsychiatric Genetics, Am J Med Genet B Neuropsychiatr Genet. 2008 Jul 10. [Epub ahead of print]
A novel locus for idiopathic generalized epilepsy in French-Canadian families maps to 10p11. Kinirons P, Verlaan DJ, Dubé MP, Poirier J, Deacon C, Lortie A, Clément JF, Desbiens R, Carmant L, Cieuta-Walti C, Shevell M, Rouleau GA, Cossette P. Am J Med Genet A. 2008 Mar 1;146A(5):578-84
Ten renin-angiotensin system-related gene polymorphisms in maximally treated Canadian Caucasian patients with heart failure. Zakrzewski-Jakubiak M, de Denus S, Dubé MP, Bélanger F, White M, Turgeon J. Br J Clin Pharmacol. 2008 May;65(5):742-51
No evidence that skewing of X chromosome inactivation patterns is transmitted to offspring in humans. Bolduc V, Chagnon P, Provost S, Dube MP, Belisle C, Gingras M, Mollica L, Busque L. J Clin Invest. 2008 Jan;118(1):333-41
Two-stage strategies to detect gene x gene interactions in case-control data. Barhdadi A, Dube MP. BMC Proc. 2007;1 Suppl 1:S135
Multistage Designs in the Genomic Era: Providing Balance in Complex Disease Studies. Dube MP, Schmidt S, Hauser E. Genetic Epidemiology, 31 (Supplement 1):S1–S6, 2007
Genetics of Congenital Amusia (or tone-deafness): A Family Aggregation Study. I Peretz, S Cummings, MP Dubé. American Journal of Human Genetics, 2007 Sep;81(3):582-8
Mutations in the UBIAD1 gene, encoding a potential prenyltransferase, are causal for Schnyder crystalline corneal dystrophy. Orr A, Dubé MP, Marcadier J, Jiang H, Federico A, George S, Seamone C, Andrews D, Dubord P, Holland S, Provost S, Mongrain V, Evans S, Higgins B, Bowman S, Guernsey D, Samuels M. PLoS ONE. 2007 Aug 1;2(1):e685
Syringomyelia in cavalier King Charles spaniels: the relationship between syrinx dimensions and pain. Rusbridge C, Carruthers H, Dubé MP, Holmes M, Jeffery ND. J Small Anim Pract. 2007 Aug;48(8):432-6
Gene-Gene Interaction Tests Using SVM and Neural Network Modeling. N Martchenko-Shimko, MP Dubé. Computational Intelligence in Bioinformatics and Computational Biology, 2007. CIBCB '07. Proceedings of the 2007 IEEE Symposium
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